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Compared to the control serum, GHK-Cu reduced wrinkle volume by 55.8% and wrinkle depth by 32.8%

Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits -glutamylcysteine synthetas (-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc system) [126, 127]

Glutathione: Overview of its Protective Roles, Measurement, Biosynthesis

In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau