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This effect is best understood in the context of gene promoters where DNA methylation can impair physical binding of transcription enhancers and promote the recruitment of methyl-CpG-binding domain proteins that increase chromatin condensation and thus decrease the DNA accessibility for the transcriptional machinery (Portela and Esteller, 2010)

Let it sit on your mattress for at least eight hours to give it time to take in the cigarette smoke odor and make your mattress smell better before vacuuming it up

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