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Although these estimates did not incorporate information related to healthrelated behaviors or health conditions, it is notable that the Southeast region also has the highest prevalence of conditions such as hypertension, stroke and diabetes that raise the risk of dementia (see Modifiable Risk Factors in the Overview)

PGC-1 inhibition reversed the beneficial effects of AMSCs in enhancing OXPHOS and mitochondria mass, as reflected by significantly diminished upregulation in OCR and mtDNA content induced by AMSCs in SR-18292-treated cells (Fig

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