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Inside cells, especially brain cells, is the most potent antioxidant of all, which is glutathione

Each sample was replicated independently thrice

Then literatures reported the Ala177Val mutation has no influence on the kinetic parameters of bacterial MTHFR, but rather reduces enzyme stability and affinity for cofactor, and thus increases the tendency to form inactive enzyme via flavin dissociation, compared to the wild-type enzyme 27