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Microglia and Their Role in CNS Pathophysiology in the Context of Nicotine Addiction Microglia are highly specialized resident immune cells of the brain and play a vital role in surveillance of the brain microenvironment, which enables them to detect and respond to perturbations by altering their own morphology based on the type of insult (105, 106)

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[28] 19th century [edit] The 19th century witnessed several significant trends in the history of tobacco, as it became increasingly popular and its consumption spread across the world