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Klomp A, den Hollander B, de Bruin K, Booij J, Reneman L (2012) The effects of ecstasy (MDMA) on brain serotonin transporters are dependent on age-of-first exposure in recreational users and animals

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A 2026 review in The American Journal of Sports Medicine found that TB-500 may show some promise in early preclinical research (meaning laboratory testing or animal research), but when it comes to high-quality human data on the benefits, were still very much in the more questions than answers phase