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Other treatments that might be more effective include: Laser Therapy: Brightening and collagen-inducing beams of the laser also work around the eyes and can erase unwanted pigmentation to eliminate dark circles

The metabolism of tryptophan leads to the decrease of tryptophan content and the accumulation of tryptophan metabolites

Combination with Other Therapies: TB-500 nasal spray can be used as a standalone therapy or in combination with other treatments or therapies

Key points Abdominal pain in chronic constipation (FC/IBS-C) stems from fecal/gas distension, gut dysbiosis (e.g., histamineproducing bacteria), serotonin imbalances (linked to IBS-C pain), and neural dysfunction (central/peripheral sensitization)