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This breakthrough has accelerated research into riboflavins role not only as a conventional dietary supplement to correct metabolic deficiencies, but also as a component of gene therapy approaches and enzyme-targeted precision medicine

To reflect these advances, Table 1 presents an updated and comprehensive summary of the pharmacological actions of SIN in various cardiovascular disease models, incorporating findings from in vitro and in vivo studies (Figure 5)

Furthermore, regulatory and quality control issues pose major barriers to clinical translation

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