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of this proposed rule where we propose to modify two hybrid measures in the Hospital IQR Programthe Hybrid Hospital-Wide All-Cause Risk Standardized Mortality measure and the Hybrid Hospital-Wide All-Cause Risk Standardized Readmission measure

Loss-of-function polymorphisms and a rare missense mutation in human CAMKK2 are associated with bipolar disorder, and genetic deletion of Camkk2 in mice causes bipolar-like behaviours similar to those in patients

Liver cirrhosis Cirrhosis is the advanced stage of liver fibrosis caused by long-term liver injury and is the main cause of death in CLDs (such as ALD, viral hepatitis, and MASLD) 70

In addition to increasing Camkk2 mRNA expression, valproate has been reported to acutely activate AMPK, which suggests that valproate may also increase CaMKK2 activity [182]