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For people who were able to quit before the age of 35, there is an even greater reduction in risk, to the point that over a period of two to three decades their risk of dying from smoking-related cancers becomes almost equivalent to a person who has never smoked

Further, our current findings corroborate conclusions drawn from previous studies done by us and others in the field [19, 21, 22, 32, 33] that indicate that IQOS is as detrimental to pulmonary health as are combustible cigarettes

Other contributing factors include air pollution, occupational exposures, and genetic conditions such as alpha-1 antitrypsin deficiency