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Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP (Haas et al., 2007)

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Nevertheless, researchers, lacking substantial evidence supporting the involvement of peripheral pain tissue anomalies and nociceptive processes in fibromyalgia, tend to emphasize the study of central sensitization [12,47]

doi: 10.3390/microorganisms9071486 410 SzntMDzsaAAntalDSzabKKemnyLBaiP