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Another proposed option does not require hospitalization, and the KD ratio is increased weekly, starting at 1:1, until a 4:1 ratio is achieved (65)

Duration of gradual systemic effect on an average individual Fair to medium brown Complexion 1-3 Months Dark Brown Complexion 1-6 Months Very dark Complexion 6-12 months Black Complexion 12-24 months 2

A later dose-response study explored the relationship between T4 dose and functional recovery after stroke, reinforcing that the effect is dose-dependent rather than all-or-nothing

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