This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses
While aluminum oxide/silicon carbide (Al 2 O 3 /SiC) and silicon nitride/silicon carbide (Si 3 N 4 /SiC) ceramic nanocomposites have received the greatest attention, other phases like titanium nitride (TiN), titanium carbide (TiC), titanium dioxide (TiO 2 ), zirconium dioxide (ZrO 2 ), chromium carbide (Cr 3 C 2 ), and yttrium aluminum garnet (YAG) can also be used as nanoreinforcements
We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins
The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis Nutrition & Metabolism20129:35 DOI: 10.1186/1743-7075-9-35
