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Foundational evidence here comes from animal models showing that CoQ10 supplementation can restore oocyte mitochondrial function in aged mice, 3 with subsequent human trials beginning to map the same pathway in clinical settings (see CoQ10 section below)

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Requires consistent use for noticeable results

Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (36, 83)