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Many studies suggest that a combination of genetic predisposition, environmental and maternal factors as well as their interactions play a significant role in the etiology of autoimmune diseases [14,15,16,17,18,19,20,21]

Integrated metabolomics and proteomics platforms revealed a marked increase in fatty acid oxidation-related metabolites, as well as proteome changes, in PDAC treated with GLS1 inhibitors, suggesting that treatments should target multiple metabolic pathways to overcome metabolic plasticity 112,113

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