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Published 2018 Dec 17

N-Acetylcysteine and hydrogen sulfide in coronavirus disease 2019

In addition to GSH, cysteine metabolism produces reactive sulfur species such as hydrogen polysulfides (H 2 S n ), which can act as nucleophilic and redox-active metabolites scavenging reactive oxygen species and lipid peroxyl radicals, thereby mitigating lipid peroxidation independently of the GPX4GSH axis [77,78]