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active lesions are enriched in collagen-producing cells, aggregates of fibronectin and collagen, mesenchymal perivascular aggregates of platelet-derived growth factor receptor (PDGFR)-bearing cells, and pro-fibrotic factors such as biglycan and decorin

Patients with primary hyperoxaluria type 2 have significant morbidity and require careful follow-up

Research has also examined BPC-157s potential effects on the nervous system, with some studies suggesting neuroprotective properties

These are uncommon, but they suggest a need for caution in people with known high hematocrit, clotting disorders or myeloproliferative conditions