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The Animal experiments of this study were approved by the Fujian Auburui Biological Laboratory Animal Ethics Committee (Approval Number: IACUC FJABR2024030101) on February 20, 2023, which precedes the start of the experiment (January 10, 2023 April 15, 2023)

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thaliana seedlings co-cultivated with the root-colonizing endophytic fungus Piriformospora indica suggesting an important role of the enzyme in the maintenance of mutualistic plant- fungal interaction (Vadassery et al., 2009)

Se-containing molecules have been investigated in various contexts: (i) tumor development and dissemination, (ii) drug delivery