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All authors declare no conflict of interest and were not involved in the journals review or desicions related to this manuscript

62 UPS-targeted therapies and induced protein degradation strategies Recent advances in targeted protein degradation have transformed the ubiquitinproteasome system into a highly versatile therapeutic platform

The pathogenic triad Researchers now describe the core of psoriasis pathology as a pathogenic triad consisting of dendritic cells, TH17 cells, and keratinocytes