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This suggests mechanisms beyond calorie restriction, including changes in gut hormones, bile acid metabolism, and the gut microbiome

When shots make sense (and when they don't) Injections are the right call in specific situations: confirmed severe deficiency, pernicious anemia (where intrinsic factor is absent), or documented malabsorption that has failed to respond to oral supplementation

Increasing the ingested dose above 5 g should be avoided since this will alter intestinal motility and water handling through its osmotic effect

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