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Mitochondrial dysfunction with loss of cytochrome c and changes in cellular redox status has been shown to alter TGF- signaling in fibroblasts, promoting fibrogenesis, and mitochondrial ROS can directly stimulate alveolar epithelial cell changes towards a profibrotic phenotype (Henderson and OReilly, 2021

Truly, diseases like lung cancers, chronic obstructive pulmonary disease (COPD) as well as heart diseases are directly linked with the effects of smoking from inhalation of hazardous compounds like tar, carbon II oxide, and carcinogens

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