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L.Martnez-GarcaA.Jimnez-HernndezE.et al (2020)

Therefore, in order to more effectively correct sleep or circadian abnormalities in psychiatric disorders, it is necessary to apply both an appropriate dose and an appropriate dosing time, according to the purpose of melatonin supplements [84, 85]

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Hepatotoxicity In response to oral exposure to MP and NP, multiple groups showed altered gut microbiome and disruption of serum and hepatic markers of amino acid synthesis and metabolism, energy, and lipid metabolism [49,50,51, 79], followed by liver inflammation [41, 69]