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While the in vitro concentrations used in the included studies (ranging from 0.5 to 400 g/mL) are difficult to translate into real-world inhalation or dermal exposure levels, available human exposure proxies (e.g., PET-specific EDI from indoor dust 4150 g/kg-bw/day in infants [56]) suggest that quantitative alignment across routes and metrics remains uncertain

Chronic oxidative stress may result from either a single bout of intense stress or repeated, chronic stress exposures

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