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Adenylosuccinate synthetase (AdSS) is an enzyme that catalyzes the condensation of IMP (inosine-5-monophosphate) with L-aspartate to adenylosuccinate

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The ROS and MAP longitudinal studies entail annual cognitive and clinical testing of participants, including medical history collection, neurological evaluation and a battery of 19 cognitive tests known to accurately characterise cognitive decline in older adults 28,29

This can manifest as brain fog, difficulty concentrating, and difficulty completing tasks