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Early Studies of the BloodBrain Barrier in the Developing Brain Dye experiments Ehrlich (1885) and Goldmann (1909) showed that parenteral injections of trypan blue and other acidic dyes resulted in staining of almost all tissues except the brain

To recruit participants, the study coordinator utilized a multifaceted approach, employing fliers, newspaper and radio advertisements, online announcements, and word-of-mouth referrals to reach potential subjects in the local Hershey/Harrisburg, PA area

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