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Recent studies have highlighted the role of mitochondrial impairment and altered energy metabolism as key contributors to the pathophysiology of GWS, with their severity correlating to disease progression in 19 veterans suffering from GWS and 17 healthy controls, comparing these factors to markers of peripheral inflammation (Golomb et al., 2023)

Wainua is a ligand-conjugated antisense oligonucleotide therapy that works by tagging the TTR mRNA for degradation, reducing the overall production and concentration of the TTR protein

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