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Hormonal changes in perimenopause can affect insulin sensitivity, muscle mass, and fat storage patterns even if diet and exercise havent changed

Mild water retention: Occasional during the first weeks, typically resolving as the cycle progresses

Cell proliferation assays For cell proliferation assays with cell counting, cells were plated in triplicates in 24-well plates at 10000 cells/well

73 Multiple mouse models have also shown that augmented expression of antioxidant enzymes, specifically isoenzymes of superoxide dismutase, protect the lung from oxidative stress, 74, 75 while deficiency in antioxidant processes results in pulmonary oxidative injury and reduced survival