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A study of moderate acne patients treated with 20 mg/day isotretinoin over approximately 6 months reported a very high efficacy rate with 98.99% of patients improving, including 98.3% who improved dramatically.3 A study of 1 mg/kg/day isotretinoin treatment over approximately 5 months in patients with severe acne reported a dose-dependent increase in efficacy with 90% of patients experiencing at least a 95% reduction in inflammatory acne 4

Clinical diagnostic scale: a useful tool in the evaluation of suspected hepatotoxic adverse drug reactions

however, this was not shown to be very effective

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