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[3] Pyroglutamic acid exists as two distinct enantiomers: (2 R ) or D which happens to be (+) or d (2 S ) or L which happens to be () or l Metabolism [edit] As first discovered in 1882, pyroglutamic acid can be formed by heating glutamic acid at 180 C, which results in the loss of a molecule of water

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Both types impair the delivery of oxygen and nutrients to body tissues

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