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Despite the devastating health consequences, including increased risk of heart disease, lung cancer, and stroke, quitting can seem like an insurmountable task

doi:10.1186/1745-6673-7-14 Nelson PR, Conrad FW, Kelly SP, Maiolo KC, Richardson JD, Ogden MW (1997) Composition of environmental tobacco smoke (ETS) from international cigarettes and determination of ETS-RSP: Particulate marker ratios

Third, PRS based on GWASs of European ancestry may limit its application in a larger population due to the differences in risk alleles, allele frequency, and the effect sizes of risk alleles