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In an uncontrolled trial in 100 men with infertility, a combination supplement containing 800 mg alpha-lipoic acid, 100 mg betaine, 400 mcg folic acid, 1,000 mg myo-inositol, 2.6 mg B12, 1.7 mg riboflavin, and 1.9 mg B6 was tested and reported to improve sperm concentration, motility, and morphology

Where the peptide enters the body determines where it concentrates, how much reaches systemic circulation, and which tissues it can reach at therapeutic levels

Whether TB-500 can achieve similar effects in the CNS remains an open question that requires dedicated research