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Primary Metabolic Pathways Beta-3-Adrenergic Receptor Modulation Research in obese mice demonstrated that AOD-9604 increases expression of beta-3-adrenergic receptor RNA in adipose tissue, upregulating levels from those seen in obese animals to levels comparable with lean controls

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Elevated NNMT expression has been observed in adipose tissue of animals with insulin resistance, and modulation of this enzyme has been shown to influence weight and metabolic function in preclinical models