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The switch to glycolysis led to an increased release of the metabolite lactate, which might be used as an additional source of energy by leukemia cells and confer chemoresistance.34 While MSC are a fundamental component of the BM niche, and contribute to its formation in vivo , other stromal cells may have a role in leukemia maintenance and protection from therapeutic agents

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J Gastroenterol Hepatol 23:e428e431

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