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These diseases are also categorically classed as proteinopathies, and comprise aggregation-prone components such as -amyloid (A) and tau in Alzheimers disease (AD), -synuclein in Parkinsons disease (PD), and polyglutamine (polyQ) repeat diseases

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Many effects are based on smaller trials, anecdotal reports, or preliminary studies

Given the heterogeneity of genetic mutations (which can take place in different positions along the DNA, thus in different genes) and the resulting increasing number of genetic mouse models that have been generated, different animal models reproduce various aspects of ASD symptomatology, with the best animal model keeping together all three types of validity criteria