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In Arabidopsis, only the plastidial GR2 is essential (Marty et al., 2019)

We have recently shown that the collateral sensitivity of resistant cells to these drugs is dependent on P-gp expression and activity, whereby stimulation of its ATPase activity triggers a rise in reactive oxygen species (ROS) leading to heightened oxidative cell death of resistance cells [14,15,16,17]

La Surdoue est aussi recommande pendant le post-partum, jusqu' 4 mois aprs l'accouchement : la perte de poids, les montes de lait et les variations hormonales fragilisent la peau mme aprs la naissance

A major shortcoming is their frequent failure to replicate human comorbidities (e.g., hypertension and diabetes), which profoundly alters copper homeostasis and cell death pathways