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SP has been reported to have anti-inflammatory effect (Usman et al., 2020), When B16F10 melanoma cells were treated with 050 m SP, it was found that SP to induce melanin synthesis in a dose-dependent manner by increasing the expression of MITF and tyrosinase via increasing CREB phosphorylation ( In vitro , SP at concentrations of 050 mol/L enhanced melanogenesis in vivo and in vitro by increasing melanin content and Tyr and MITF expression (Heriniaina et al., 2018)

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[111,112] Furthermore, microRNA125a-loaded nanoparticles have also been found to restore homeostasis and ameliorate murine lupus by regulating the balance between T effector cells and T regs