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They conclude and rationalise by suggesting that the effect of Nrf2 activation is largely related to the biological time context, stating that Nrf2 activity is desirable (for the host organism) in early stages of tumourigenesis, when the host is seeking to control premalignant carcinogenesis, but is undesirable in later stages of tumourigenesis, when it could make fully malignant cancer cells become resistant to treatment

Toxicology 149:4350 Thomas C, Mackey MM, Diaz AA, Cox DP (2009) Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

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