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SAHA treatment increased survival of dopaminergic neurons in mesencephalic neuronal culture, which was evident by an increase in percentage of dopamine uptake ( HDAC Inhibitors in Neuronal Differentiation HDAC inhibitors induce histone acetylation in diseased neurons and may reinstate transcriptional stability and hence delay or prevent cell degeneration (Sterner and Berger, 2000)

doi: 10.1016/j.brainres.2016.04.060 88 GiriBBelangerKSeamonMBradleyEPurohitSChongRet al

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Mousa, MBBS, MD Chair for Gastroenterology, Mayo Clinic Health System Southwest Minnesota region, Mankato, Minnesota