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Moreover, smoking increases oxidative stress by inducing the production of reactive oxygen species (ROS), which directly damage cellular structures such as lipids, proteins, and DNA, contributing to tissue inflammation, cellular dysfunction, and the progression of chronic diseases

This was partly due to the etiquette of entertaining, but also because lighters were not as safe or small back then, and you stood less of a chance of lighting yourself on fire or having gunpowder leak into your pocket if you just relied on the lighter offered by the host

The forced swim test is a behavioural despair test in rodents used to screen anti-depressant drugs, which involves placing a mouse or rat in a beaker of water and forcing them to swim, offering no escape route

January 20, 1896 March 9, 1996) was an American comedian, actor, writer, and singer, and one of the few entertainers whose career successfully spanned vaudeville, radio, film, and television