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Pseudomonas can produce lipopolysaccharide (LPS) and peptidoglycan (PGN), which act on Toll-like receptor 4 (TLR4) and NOD-like receptors (NLRs), thereby activating host immune responses ( Pseudomonas was significantly negatively correlated with biotin (vitamin B7) levels ( In addition to baseline dysbiosis, disease stage and treatment status also influence gut microbiota taxonomic composition