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Phase 2 dose-ranging trials followed in 20042006, and the pivotal Phase 3 trials (studies LIPO-010-05 and LIPO-010-06) ran from 2006 to 2009 , forming the efficacy basis for the November 2010 FDA approval

Chapter 6: Improving Integration for Dually Eligible Beneficiaries: Strategies for State Contracts with Dual Eligible Special Needs Plans

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Cells continuously overexpress the iron export mechanism by transporting ferritin and iron through MVBs/exosomes, thereby limiting the accumulation of iron within the cells and inhibiting ferroptosis