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Typical endpoints include lesion size reduction, mucosal histology, and markers of epithelial repair

With studies characterising reduced neuronal death, promotion of axonal outgrowth and functional recovery in spinal cord injury models, neuroprotection in traumatic brain injury models, and modulation of dopaminergic and serotonergic pathways relevant to both neuroprotection and behavioural recovery

(23) Kinetics of hydrolysis of acetylthiocholine and acetylcholine by cholinesterases

When symptoms are attributed to high B12 intake, they typically include: Skin reactions : Acne-like eruptions or rosacea-type rashes, particularly with hydroxocobalamin injections (listed as rare adverse effects in the product information) Gastrointestinal disturbances : Mild nausea, diarrhoea, or abdominal discomfort Headaches : Occasional reports of headache following B12 injections Anxiety or restlessness : Anecdotal reports, though causation remains unestablished It is crucial to distinguish between symptoms caused by elevated B12 levels and those arising from the underlying conditions that elevate B12