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While several clinical studies examined the favorable effect of reduced GSH short-term or long-term administration on alcohol-induced liver diseases (7276), the available literature on the effect of GSH on NAFLD is limited -see Table 1-, and the studies at hand are to be considered pilots (7779)

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The occurrence and development of different diseases are associated with abnormal GSH metabolism through different mechanisms: Glutathione dynamics during sepsis Sepsis is characterized by severe redox imbalance, and glutathione plays a key role in combating oxidative and nitrosative stress