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For example, various signaling and regulatory proteins that contain intrinsically disordered regions (IDRs) have been shown to be degraded by the 20S proteasome, including the tumor suppressors p53, p73, and retinoblastoma protein, the proto-oncoprotein c-Fos, the cell cycle regulators p27 and p21 and the neurodegenerative disease-related proteins tau and -synuclein (Ben-Nissan and Sharon, 2014b

The researchers reported that the GHRP-2 models ate an average of 36% more than the saline group, with each model reportedly exhibiting increased food intake when measured against their respective body weight

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