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PMID: 30915550 Malinda KM, et al

Vitamin B12 injections are a safe and effective way to treat B12 deficiency, and we commonly recommend them for patients who have trouble absorbing this essential vitamin from food or oral supplements

They are polarized tissues due to the differential expression of ion channels, pumps and transporters in the apical and the basolateral sides: (a) epithelial sodium channels (ENaC), Ca 2+ activated chloride channels and the cystic fibrosis transmembrane conductance regulator (CFTR) are present in the apical plasma membrane and (b) the Na + -K + -ATPase ion pump and the Na + -K + -2Cl cotransporter in the basolateral side

Int J Clin Exp Med (2012) 5:20820