Oxidative and nitrosative stress are furthermore known to promote protein S -glutathionylation [64], nitrosylation, and sulfenylation, which can regulate and affect central redox-regulated metabolic processes
Kinyanjui MW, Shan J, Nakada EM, Qureshi ST, Fixman ED
On re-exposure, the drug-protein conjugate cross-links its IgE which bound to the high-affinity receptor and induces the degranulation of mast cells and basophils, and release of inflammatory mediators that induce urticaria, vasodilatation, increased vascular permeability, edema and bronchoconstriction, leading to cardiovascular failure, bronchospasm and even death 2,10
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