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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

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Results showed a statistically significant improvement in skin firmness (+22% on cutometer), dermal density (+18% on high-frequency ultrasound) and periorbital wrinkle depth (-25% on profilometry)