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Studies have shown that oxidative stress upregulates the expression of intercellular adhesion molecule 1(ICAM-1) in epithelial cells through an IL-6/AKT/ST4T3/NF-KB dependent pathway, and its upregulation is closely related to pro-inflammatory cytokines such as IL-6, IL-1, and TNF- (44)

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Contributory factors in addition to, or likely due to the described effect on vessel recruitment [20,21,22,23,24,25,26,27], may be that BPC 157 counteracts in rats various encephalopathies [33,34,35,36,37,38,39,40,41]

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