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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs

Surg Today 2007

Primary testicular cell cultures, including isolated Sertoli cells and spermatogonial stem cells, provide tractable systems for investigating EED effects on specific cellular functions

By binding S1P receptors on ovarian endothelial and granulosa cells, these agents inhibit intrinsic caspase activation and preserve follicle vascularity in murine models receiving cyclophosphamide or ionising radiation, without blunting antitumour efficacy [127,128,129,130,131]