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In individuals with confirmed B12 deficiency, correction may help normalise homocysteine metabolism, as deficiency has been associated with elevated homocysteine levels

NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability

Unnecessary vitamin B12 shots costing Ontario millions, study finds Most seniors getting B12 shots in province don't need them, researchers say Almost two-thirds of Ontario seniors who received vitamin B12 shots had no evidence of a B12 deficiency, according to a study published in the medical journal JAMA Internal Medicine

Blood tests measuring serum B12, methylmalonic acid, and homocysteine levels help assess deficiency